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Schubert, W.,

Journal of Biotechnology, Vol. 149, Iss. 4, 2010
On the origin of cell functions encoded in the toponome.

Journal of Proteome Research, Vol. 9, Iss. 12, 2010
Toponome imaging system: in situ protein network mapping in normal and cancerous colon from the same patient reveals more than five-thousand cancer specific protein clusters and their subcellular annotation by using a three symbol code.

Press release, 2010 (German)
Mediziner der Universitaet Magdeburg lehrt Computervisualisierung von Protein-Netzwerken in den USA.

Journal of Proteome Research, Vol. 8, Iss. 6, 2009
Toponome mapping in prostate cancer: detection of 2000 cell surface protein clusters in a single tissue section and cell type specific annotation by using a three symbol code.

Press release, 2008 (German)
Magdeburger Wissenschaftler erhielt internationalen Forschungspreis.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1783, Iss. 11, 2008
Functional architecture of the cell nucleus: Towards comprehensive toponome reference maps of apoptosis.

Press release, 2008 (German)
Magdeburger Wissenschaftler wurde in Shanghai zum ersten Gastprofessor für Toponomics ernannt.

Proteomics, Vol. 8, Iss. 6, 2008
Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus.

Press release, 2007 (German)
Protein Cluster der Zelloberfläche erstmals sichtbar gemacht.

Nature Protocols, Vol 2, No 10, 2007
Cover image in Nature Protocols: Toponome colocalization map of a CD4 T-lymphocyte.

Nature Protocols, Vol 2, No 9, 2007
Fluorescence detection of protein clusters in individual cells and tissue sections by using toponome imaging system: sample preparation and measuring procedures.

Cytometry Part A, Vol. 71A, Iss. 10, 2007
Breaking the biological code

Cytometry Part A, Vol. 71A, Iss. 6, 2007
A Three-Symbol Code for Organized Proteomes Based on Cyclical Imaging of Protein Locations.

Nature Methods, Vol 4, 2007
Toponome Imaging System (TIS): Imaging the proteome with functional resolution.

BMBF singles out TI Spin Off - breakthrough in proteomics, 2006 (German)
Komplexer Schnappschuss in die Zelle hält hunderte Eiweiße gleichzeitig fest.

Foundation of Toponome Centres
TNL announces the foundation of several Toponome Centres in Europe.

Nature Biotechnology, Vol 24, 2006
Analyzing proteome topology and function by automated multidimensional fluorescence microscopy.

Press release, 2006 (German)


Nattkemper T.W., Schubert W., Hermann T., Ritter H. A Hybrid System for Cell Detection in Digital Micrographs. In: Tilg B, ed. Biomedical Engineering, Proc. Vol 417. Innsbruck, Austria: ACTA Press; 2004.

Grygierzec W., Deutsch A., Philipsen L., Friedenberger M., Schubert W. Modelling tumour cell population dynamics based on molecular adhesion assumptions.
J. Biol. Sc. 12:  273-288 (2004)

Nattkemper T.W., Hermann T., Schubert W., Ritter H.  Look & Listen: Sonification and Visualization of Multiparameter Micrographs. In: Engineering in Medicine and Biology Society. Proceedings of the 25th Annual International Conference of the IEEE. Vol 2. Cancun, Mexico.
IEEE Proceedings of the 25th Ann. Intntl. Conf. of the IEEE 2:  1311-1314 (2003)

Nattkemper T.W., Twellmann T., Ritter H., Schubert W.  Human vs. Machine: evaluation of fluorescence micrographs.
Computers in Biology and Medicine 33(1): 31-43 (2003)

Schubert W. Topological proteomics, Toponomics, MELK Technology.
Adv Biochem Eng Biotechnol 83: 189-209 (2003)

Nattkemper T.W., Wersing H., Schubert W., Ritter H. A neural network architecture for automatic segmentation of fluorescence micrographs. 
Neurocomputing 48 (Elsevier science BV): 357-367 (2002)

Schubert W. Polymyositis, Topological Proteomics Technology and Paradigm for Cell Invasion Dynamics.
J Theor. Med.  4 (1): 75–84  (2002)

Twellmann T., Nattkemper T.W., Schubert W., Ritter H. Cell Detection in Micrographs of Tissue Sections Using Support Vector Machines. In: Proc. Of. ICANN 2001 Workshop on Kernel and Subspace Methods for Computer Vision. (2001)

Nattkemper T.W., Ritter H., Schubert W. A neural classifier enabling high-throughput topological analysis of lymphocytes in tissue sections.
IEEE transactions on information technology in biodemicine 5(2): 138-149 (2001)

Nattkemper T.W., Wersing H., Schubert W., Ritter H.J. Automatic Evaluation of Multi-Parameter Fluorescence Micrographs with a Neural Network Architecture. In: Proc. of the Mathematical and Engineering Techniques in Medical and Biological Sciences (METMBS 2000), Conference Paper, Las Vegas; 2000:739-744 (2000)

Nattkemper T.W., Wersing H., Schubert W., Ritter H. Fluorescence Micrograph Segmentation by Gestalt-Based Feature Binding. In: Proc. Of the Int. Joint Conf. On Neur. Netw. (IJCNN). Vol 1. Como, Italy; 2000: 248-254 (2000)

Hermann T., Nattkemper T.W., Schubert W., Ritter H. Sonification of Multi-Channel Image Data. In: Falavar V, ed. Proc. Of the Mathematical and Engineering Techniques in Medical and Biological Sciences. Las Vegas: CSREA Press; 745-750 (2000)

Nattkemper T.W., Ritter H., Schubert W. Extracting Patterns of Lymphocyte Fluorescence from Digital Microscope Images. In: Intelligent Data Analysis in Medicine and Pharmacology (IDAMAP 99), Workshop Notes. AMIA 1999, Washington DC; 1999: 79-88 (1999)

Ademmer K., Ebert M., Müller-Ostermeyer F., Friess H., Büchler M.W., Schubert W., Malfertheiner P. Effector T Iymphocyte subsets in human pancreatic cancer: detection of CD8+CD18+ cells and CD8+CD103+ cells by multi-epitope imaging.
Am J. Gastroenterol. 11: 2141-2147 (1998)

Ebert M., Müller-Ostermeyer F.,  Ademmer K., Friess H., Büchler M.W., Schubert W. Malfertheiner P. CD8+CD103+ cells analogous to intestinal intraepithelial Iymphocytes infiltrate the pancreas in chronic pancreatitis.
Clin. Exp. Immunol. 112: 21-26 (1998)

Kuznetsov A.V., Mayboroda O., Kunz D., Winkler K., Schubert W., Kunz W.S. Functional imaging of mitochondria in saponin-permeabilized mice muscle fibers.
J Cell Biol. 140(5): 1091-9 (1998)

Schubert W., Agha-Amiri K., Mayboroda O., Rethfeldt C. Dipeptidyl peptidase IV (CD26) and Alzheimer amyloid precursor (APP) in polymyositis.
Adv. Exp. Med. Biol. 421: 273-277 (1997)

Schubert W., Schwan H. Detection by 4-parameter microscopic imaging and increase of rare mononuclear blood leukocyte types expressing the Fc gamma receptor (CD16) for immunoglgulin G in human sporadic amyotrophic lateral sclerosis (ALS).
Neurosci Lett. 198(1): 29-32 (1995)

Schubert W., Masters, C.L., Beyreuther K.: APP+ T lymphocytes selectively sorted to  endomysial  tubes in polymyositis displace NCAM-expressing muscle fibers.
Eur. J.  Cell Biol. 62(2):333-42 (1993)

Beyreuther K., Pollwein P., Multhaup G., Mönning U., König G., Dyrks T., Schubert W.,  Masters C.L. Regulation and Expression of the Alzheimer´s betaA4 amyloid protein precursor in  health,  disease, and Down´s syndrome. 
Ann. N.Y. Acad. Sci. 695: 91-102  (1993)

Schubert W.  Antigenic determinants of T lymphocyte a/b receptor and other leukocyte  surface proteins as differential markers of skeletal muscle regeneration: detection of spatially and timely  restricted patterns by MAM microscopy.
Eur. J. Cell  Biol. 58: 395 – 410 (1992)

Schubert W., Haraldsen G., Pfaffenbach B., Jerusalem F.  Quantitative Untersuchungen zur  Expression multipler Phänotypen der Muskelfasern und Kapillaren bei der Polymyositis.  In: Aktuelle  Myologie, pp. 45-48, Urban und  Schwarzenberg Verlag, München - Wien - Baltimore.  (1992)  

Schubert, W., Beyreuther, K.  Modell der T Zellinvasion der Polymyositis: Muskel-NCAM Komplex  als "Docking Protein" für T Zell - assoziierte Alzheimer Amyloid Vorläuferproteine . In: Aktuelle  Myologie, pp. 49-53, Urban und  Schwarzenberg Verlag, München - Wien - Baltimore. (1992)

Beyreuther, K., Bush, A.I., Dyrks, T., Hilbich, C., König, G., Mönning, U., Multhaup,  G., Prior, R.,  Rumble, B., Schubert, W., Small, D.H., Weidemann, A., Masters, C.L.  Mechanisms of amlyoid  deposition in Alzheimer´s disease. In: Growden, J.H., Corkin, S., Ritter-Walker, E., Wurtmann, R.J.  (eds.). Aging and Alzheimer´s disease. Sensory systems, neuronal growth, and neuronal metabolism.
Ann. NY Acad. Sci. 640: 129 - 139 (1991)

Schubert W. Triple immunofluorescence confocal laser scanning microscopy: spatialcorrelation of novel cellular differentiation markers in human muscle biopsies.
Eur. J. Cell Biol. 55:  272 - 285 (1991)

Schubert W., Prior R., Weidemann A., Dircksen H.,  Multhaup G., Masters C.L., Beyreuther K. Localization of Alzheimer betaA4 amyloid precursor protein at central and peripheral synaptic sites. 
Brain Res. 563:  184 - 194  (1991)

Schubert, W.: Immunzytochemie und Affinitätszytochemie. In: F. Jerusalem, S. Zierz (eds): Muskelerkrankungen. Thieme , Stuttgart, 73- 99 (1991)

Harding A.E., Anderton B.H., Beyreuther K., Dyrks T., Goedert M., Goldgaber D.Y., Masters C.L., Prusiner S.B., Schubert W., Sisodia S.S., Tanzi R.E.,  Unterbeck A.J.  Molecular genetic mechanisms of neurological diseases and prospects  for therapy.  Dahlem Workshop Reports. Wiley & Sons . Chichester , 251 - 258 (1990)

Schubert W.:  Multiple antigen - mapping microscopy of human tissue. In: G.  Burger, M.  Oberholzer, G.P. Vooijs (eds.).   Excerpta medica.Elsevier, Amsterdam.
Adv. Analyt. Cell.  Pathol. Pp 97 – 98  (1990)

Beyreuther K., Dyrks T., Multhaup G., Salbaum J.M.,  Schubert W., Weidemann  A. ,  Masters C.L.  Molecular genetics of dementia of Alzheimer´s type: Towards  an  early  warning and treatment of individuals at risk. In: C.J. Fowler et al. (eds.):   Biological markers  in Dementia of Alzheimer´s type.  Smith -Gordon, London, 49- 60 ( 1990)

Beyreuther K., Multhaup G., Salbaum L.M.,  Weidemann A., Dyrks T.,  Hilbich C.,  Fischer P., Bunke D., König G., Mönning U., Beer J., Schubert W., Masters C.L.  The  role  of the Amyloid (PAD/APP) gene in Alzheimer´s disease. Molecular  pathology and therapeutic implications.  In: H. Kewitz,  T. Thomsen, U. Bickel  (eds):  Pharmacological  interventions on central cholinergic mechanisms in senile  dementia (Alzheimer´s disease).  W. Zuckerschwerdt, München,65-72  (1989)

Schubert, W., Zimmermann, K., Cramer, M., Starzinski-Powitz, A. Lymphocyte antigen Leu19 as a molecular marker of regeneration in human skeletal muscle.
Proc. Natl.  Acad. Sci. USA  86:  307 - 311 (1989)

Zimmermann K.,  Herget T.,  Salbaum J., Schubert W.,  Hilbich C., Cramer M.,  Masters C.L., Multhaup G., Kang J., Lemaire H.G., Beyreuther K., Starzinski -  Powitz A.  Localization of the putative precursor of Alzheimer´s disease  - specific  amyloid at  nuclear envelopes of adult human muscle.
EMBO J. 7: 367 - 372 (1988)

Schubert W., Kontozis L., Sticker G., Schwan H., Haraldsen G., Jerusalem F. Immunofluorescent evidence for presence of interleukin - 1 in normal and diseased human skeletal muscle. 
Muscle Nerve 11: 890 - 892 (1988)

Jerusalem, F.,  Zierz, S.,  Schubert, W. Carnitin und Myopathie bei Kindern und Erwachsenen. In:  R. Gitzelmann, K. Baerlocher, B. Steinmann (eds): Carnitin in der Medizin,  Schattauer , Stuttgart , 71-78 (1987.

Jerusalem F., Bleistein J.,  Reuschenbach Ch., Schubert W., Zierz S.  Belastungsmyopathien.  Belastungsinduzierte, in Ruhe reversible Paresen, Myalgien  und  Kontrakturen. In: U. Gerlach, H. H.  Matthiaß (eds.): Colloquia  rheumatologica 34.  Werk  - Verlag Dr. Edmund Banaschewski. München -  Gräfelfing, 11-22 ( 1987)

Schubert W. Jerusalem F. Möglichkeiten und Technik der Muskelbiopsie.  
Deutsches Ärzteblatt 83, Heft 12:  800 - 804 (1986).

Schubert W. Polymyositis (PM): Mehrfachmarkierung und Phänotypisierung mononukleärer Zellen  (MNZ) in Infiltraten und im Blut: Analyse im Fluoreszenz  - und Laser Scan Mikroskop.  In: K. Poeck, W. Hacke, R. Schneider (eds): Verhandlungen  der Deutschen Gesellschaft für Neurologie  Band 4. Springer, Berlin/Heidelberg, 518 -  521 (1986)

Clarenbach, P., Niese D., Schubert W. Jerusalem F. Arthralgie und  neurologisches Defizit.  Ein differentialdiagnostischer Überblick. 
Nervenarzt   56:   393 - 398 (1985)

Tackmann W., Noack E., Hartmann A., Schubert W. Kearns - Sayre - Syndrom. In:  Fortschritte der Myologie. Band VIII. Gutenberg , Freiburg i. Br.,  189 -  195  (1985)

Vogel P., Schubert W., Stefan H., Paetzke I., Hollmann W. Diätetische  Behandlung des adulten Saure Maltase - Mangels. In: Fortschritte der Myologie.  Band VIII.  Gutenberg, Freiburg i. Br.,  123 - 132(1985).

Reuschenbach C., Paetzke I., Schubert W., Jerusalem F. Mitochondrien - Lipid  - Glycogen Myopathie mit Cytochrom C Oxidase Mangel. In: Fortschritte der  Myologie. Band VIII.  Gutenberg, Freiburg i. Br., 175 - 183  (1985).

Breiden- Arens C., Schubert W., Vogel, P., Jerusalem, F. Phosphorylase Mangel  Myopathie -  Spezielle klinische Aspekte. In: Fortschritte der Myologie. Band  VIII,  Gutenberg,  Freiburg i. Br., 133 - 138  (1985).

Bleistein J., Deufel Th., Schubert W., Jerusalem F. Diagnostische Probleme  beim  Adenylatdeaminase Mangel.   In: Fortschritte der Myologie. Band VIII. Gutenberg,  Freiburg i. Br.,  139 - 144  (1985).

Schubert W., Paetzke J., Deufel Th., Jerusalem F.  Der Carnitin - Palmityl  Transferase   (CPT)  Mangel.  Zwei Kasuistiken. In:  Fortschritte der Myologie. Band  VIII. Gutenberg,   Freiburg i. Br., 244 - 254  (1985).

Schubert W., Vogel P., Paetzke I. Neurogene Befunde bei adultem Saure Maltase Mangel (SMM). In:  Verhandlungen der Deutschen Gesellschaft f. Neurologie,  Band  3,Springer, Berlin/Heidelberg, 868-870  (1984) .

Willeit J., Jerusalem F., Boxler K., Schubert, W., Tolksdorf K. Häufigkeit und diagnostische Bedeutung der Einschlußkörperchen, Kritik an der  Bezeichnung "Einschlußkörperchenmyositis". In: Fortschritte der Myologie. Band VII. Gutenberg , Freiburg i. Br., 374-381 (1983).

Schubert W., Boxler K.,  Jerusalem F., Willeit, J. Neurogene Befunde bei Facio- Scapulo-Humeralen Syndromen. In: Fortschritte der Myologie. Band VII. Gutenberg, Freiburg i. Br., 157-164 (1983).

Wartenberg H., Schubert W. Pinealorgan und Hoden: Morphologische Untersuchungen zur Wirkung des Lichtentzugs auf die Spermatogenese des Goldhamsters.
Verh. Anat. Ges. 70: 69-76 (1976)

Schubert, W. Lichtmikroskopische Untersuchungen über die Beeinflussung  der Spermatogenese durch Lichtentzug beim Goldhamster (Mesocricetus auratus). Diss. Bonn (1977).


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