From genome to toponome: the next big challenge in human biology

After having deciphered the human genome deciphering the molecular networks of the cell, encompassing the myriads of cellular functionalities, is the next big challenge in human biotechnology. The precise knowledge of this entire functional plan, called the toponome, is the prerequisite to understand the cellular functions of proteins and other elements of spatially determined molecular networks. The first elementary Imaging Cycler® robot technology (a system for the imaging of the toponome) capable to decipher toponomes directly in a cell or tissue has been established. It is the result of 20-years of continuous technology development. It runs cycles of fluorescence tagging and imaging in situ. This technology combines several advances:

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MUSIC robotics

The Imaging Cycler (IC) robotics method is today more precisely referred to as MUSIC robotis (Molecular Unlimited Systems Imaging Cycler Robotics). It is based on the solar light theory (W Schubert, Island of KOS, Greece, 1987), which states that one can transmit a quasi unlimited number of distinct biological information without steric hindrance through one and the same fluorescence channel with only one sun-scattering-like stimulus, to measure the high-dimensional combinatorial molecular system directly in the tissue: the principle of the n-dimensional quasi-channels. Overview: click here. The first proof of this method was published in 1990 in a short two-page paper (Schubert W. Multiple Antigen Mapping Microscopy of Human Tissue. In: Advances in Analytical Cellular Pathology. Burger G. Oberholzer M. Vooijs G.P. (Eds.) Elsevier Science Inc. New York, 1990). Please find here a brief technology overview.

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